Abstract Urolithiasis or urinary stone disease has been estimated to affect about 1 in 11 Americans. Patients with urinary stone disease commonly present to the emergency department for management of their acute pain. In addition to providing analgesia, administration of drug (medical expulsive therapy) is often prescribed to assist passage of the urinary stone. In this methodology paper, we describe the design of a prospective, multi-center, randomized, double-blind placebo controlled clinical trial of the alpha-adrenergic blocker, tamsulosin, to evaluate its effectiveness as medical expulsive therapy. In addition, we describe the unique challenges of conducting a trial of this type within the setting of the emergency department.
Reference Type
Journal Article
Periodical Full
Contemporary Clinical Trials
Publication Year
2016
Volume
52
Start Page
91
Other Pages
94
Publisher
Elsevier Inc
Place of Publication
United States
ISSN/ISBN
1551-7144
Document Object Index
10.1016/j.cct.2016.11.010
URL
https://www.clinicalkey.es/playcontent/1-s2.0-S1551714416304438
PMID
27890522