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Submitted by bstumbo on Tue, 01/26/2021 - 20:36

OBJECTIVE: We sought to determine if there is an association between fibroblast growth factor 21 (FGF21) levels and a history of gestational diabetes mellitus (GDM) in women with and without metabolic dysfunct defined as a diagnosis of metabolic syndrome or type 2 diabetes (T2DM), 5 to 10 years following participation in a multiple cohort GDM study. STUDY DESIGN: At 5 to 10 years after index pregnancy, women underwent a follow-up visit and were categorized as having no metabolic syndrome, metabolic syndrome, or T2DM. FGF21 levels were compared between women who did and did not have a history of GDM using multivariable linear regression. RESULTS: Among 1,889 women, 950 underwent follow-up and 796 had plasma samples analyzed (413 GDM and 383 non-GDM). Total 30.7% of women had been diagnosed with T2DM or metabolic syndrome. Overall, there was no difference in median FGF21 levels in pg/mL between the prior GDM and non-GDM groups (p = 0.12), and the lack of association was observed across all three metabolic categories at follow-up (p for interaction = 0.70). CONCLUSION: There was no association between FGF21 levels and prior history of mild GDM in women with and without metabolic dysfunction 5 to 10 years after the index pregnancy (ClinicalTrials.gov number, NCT00069576, original trial).

Primary Author
Durnwald,C.
Mele,L.
Landon,M. B.
Varner,M. W.
Casey,B. M.
Reddy,U. M.
Wapner,R. J.
Rouse,D. J.
Tita,A. T. N.
Thorp,J. M.
Chien,E. K.
Saade,G. R.
Peaceman,A. M.
Blackwell,S. C.
Eunice Kennedy Shriver National Institute of Child Health Human Development (NICHD) Maternal Fetal Medicine Units (MFMU) Network
Reference Type
Journal Article
Periodical Full
American Journal of Perinatology
Publication Year
2020
Publication Date
June 23
Publisher
USA
Place of Publication
United States
ISSN/ISBN
1098-8785
Author Address
Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania.; George Washington University Biostatistics Center, Washington, District of Columbia.; Department of Obstetrics and Gynecology, The Ohio State Unive(TRUNCATED)
Accession Number
PMID: 32575141
Document Object Index
10.1055/s-0040-1712966 [doi]
PMID
32575141
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