Persons with type 1 diabetes are at high risk for kidney disease. In this study, intensive diabetes therapy administered early in the course of type 1 diabetes reduced the long-term risk of an impaired glomerular filtration rate. An impaired glomerular filtration rate (GFR) is the final common pathway of diabetic kidney disease. Once the GFR is impaired, cardiovascular disease events and progression to end-stage renal disease occur at unacceptably high rates, even with proven medical management. 1 – 3 This underscores the need for the primary prevention of impaired GFR in persons with diabetes. The Diabetes Control and Complications Trial (DCCT) and the observational study that followed it, the Epidemiology of Diabetes Interventions and Complications (EDIC) study, showed that intensive diabetes therapy that lowered glycated hemoglobin levels reduced the risk of microalbuminuria and macroalbuminuria among persons with type 1 . . .
Reference Type
Journal Article
Periodical Full
The New England journal of medicine
Publication Year
2011
Publication Date
Dec 22,
Volume
365
Issue
25
Start Page
2366
Other Pages
2376
Publisher
Massachusetts Medical Society
Place of Publication
United States
ISSN/ISBN
0028-4793
Document Object Index
10.1056/NEJMoa1111732
URL
http://dx.doi.org/10.1056/NEJMoa1111732 http://dx.doi.org/10.1056/NEJMoa1111732