Plasma Prekallikrein Is Associated With Carotid Intima-Media Thickness in Type 1 Diabetes

Publication Description
The hypothesis that plasma prekallikrein (PK) is a risk factor for the development of vascular complications was assessed in a study using the Diabetes Control and Complications Trial (DCCT)/Epidemiology and Diabetes Interventions and Complications (EDIC) cohort of subjects with type 1 diabetes. The circulating levels of plasma PK activity were measured in the plasma of 636 subjects with type 1 diabetes (EDIC years 3-5). Common and internal carotid intima-media thickness (IMT) were measured by B-mode ultrasonography in EDIC years 1 and 6. Plasma PK levels were positively and significantly associated with BMI, hemoglobin A1c, systolic blood pressure, total cholesterol, LDL cholesterol, and triglycerides but not with age, sex, duration of diabetes, or HDL cholesterol. Univariate and multivariable statistical models after controlling for other risk factors consistently demonstrated a positive association between plasma PK and progression of internal carotid IMT. Multivariate analysis using a general linear model showed plasma PK to be significantly associated with progression of both internal and combined IMT (Wilks Λ P value of 0.005). In addition, the mean internal carotid IMT levels were higher in subjects with plasma PK levels in the highest 10th percentile compared with subjects with plasma PK levels in the lower 10th percentile (P = 0.048). These novel findings implicate plasma PK as a risk factor for vascular disease in type 1 diabetes.

Primary Author
Jaffa,Miran A.
Luttrell,Deirdre
Schmaier,Alvin H.
Klein,Richard L.
Lopes-Virella,Maria
Luttrell,Louis M.
Jaffa,Ayad A.

Volume
65

Issue
2

Start Page
498

Other Pages
502

Publisher
American Diabetes Association

URL
https://www.ncbi.nlm.nih.gov/pubmed/26603531 https://www.ncbi.nlm.nih.gov/pubmed/26603531



Reference Type
Journal Article

Periodical Full
Diabetes (New York, N.Y.)

Publication Year
2016

Place of Publication
United States

ISSN/ISBN
0012-1797

Document Object Index
10.2337/db15-0930