SUMMARY Clinical management of chronic diseases requires periodic evaluations. Subjects transition between various levels of severity of a disease over time, one of which may trigger an intervention that requires treatment. For example, in diabetic retinopathy, patients with type 1 diabetes are evaluated yearly for either the onset of proliferative diabetic retinopathy (PDR) or clinically significant macular edema (CSME) that would require immediate treatment to preserve vision. Herein, we investigate methods for the selection of personalized cost-effective screening schedules and compare them with a fixed visit schedule (e.g., annually) in terms of both cost and performance. The approach is illustrated using the progression of retinopathy in the DCCT/EDIC study.
Reference Type
Journal Article
Periodical Full
Biostatistics
Publication Year
2018
Publication Date
Jan 1,
Volume
19
Issue
1
Start Page
1
Other Pages
13
Publisher
Oxford University Press
Place of Publication
England
ISSN/ISBN
1465-4644
Document Object Index
10.1093/biostatistics/kxx009
URL
https://www.ncbi.nlm.nih.gov/pubmed/28430872
PMID
28430872