This multicenter study examined the impact of albumin excretion rate (AER) on the course of estimated glomerular filtration rate (eGFR) and the incidence of sustained eGFR 300 mg/24 h) before they reached stage 3 chronic kidney disease. Macroalbuminuria is associated with a markedly increased rate of fall in eGFR (5.7%/year vs. 1.2%/year with AER <30 mg/24 h, P < 0.0001) and risk of eGFR <60 ml/min/1.73 m(2) (adjusted hazard ratio 15.3, P < 0.0001), whereas microalbuminuria had weaker and less consistent effects on eGFR. Macroalbuminuria was a strong predictor of eGFR loss and risk of developing sustained eGFR <60 ml/min/1.73 m(2). However, screening with AER alone would have missed 24% of cases of sustained impaired eGFR.
Reference Type
Journal Article
Periodical Full
Diabetes care
Publication Year
2010
Volume
33
Issue
7
Start Page
1536
Other Pages
1543
Publisher
American Diabetes Association
Place of Publication
Alexandria, VA
ISSN/ISBN
0149-5992
Document Object Index
10.2337/dc09-1098
URL
https://www.ncbi.nlm.nih.gov/pubmed/20413518 https://www.ncbi.nlm.nih.gov/pubmed/20413518