Chorionic mosaicism: Association with fetal loss but not with adverse perinatal outcome

Publication Description
Cytogenetic data from the United States NICHD collaborative study of chorionic villus sampling (CVS) were used to evaluate the clinical significance of chorionic mosaicism. The 10,754 patients with normal cytogenetic results were compared with 108 patients (1.0 per cent) with placental mosaicism and 181 patients (1.6 per cent) with pseudo-mosaicism. Of the pregnancies intended to continue, the pregnancy loss rate was significantly greater in patients with placental mosaicism than in the cytogenetically normal cohort (8.6 vs. 3.4 per cent, p less than 0.05). However, there was no difference in the frequencies of abruptio placenta, preterm labour or delivery, small-for-gestational-age newborns, pregnancy-induced hypertension, or neonates with Apgar scores less than 7.

Primary Author
Wapner,R. J.
Simpson,J. L.
Golbus,M. S.
Zachary,J. M.
Ledbetter,D. H.
Desnick,R. J.
Fowler,S. E.
Jackson,L. G.
Lubs,H.
Mahony,R. J.

Volume
12

Issue
5

Start Page
347

Other Pages
355

URL
https://www.ncbi.nlm.nih.gov/pubmed/1523202

PMID
1523202



Reference Type
Journal Article

Periodical Full
Prenatal diagnosis

Publication Year
1992

Publication Date
May

Place of Publication
England

ISSN/ISBN
0197-3851

Document Object Index
10.1002/pd.1970120504