Corrections for Bias in Maximum Likelihood Parameter Estimates Due to Nuisance Parameters

In his Fisher Lecture, Efron (Efron, B. R. A. ( 1998 ). Fisher in the 21st Century (with discussion). Statistical Science 13:95-122) pointed out that maximum likelihood estimates (MLE) can be badly biased in certain situations involving many nuisance parameters. He predicted that with modern computing equipment a computer-modified version of the MLE that was less biased could become the default estimator of choice in applied problems in the 21st century. This article discusses three modifications-Lindsay's conditional likelihood, integrated likelihood, and Bartlett's bias-corrected estimating function. Each is evaluated through a study of the bias and MSE of the estimates in a stratified Weibull model with a moderate number of nuisance parameters. In Lindsay's estimating equation, three different methods for estimation of the nuisance parameters are evaluated-the restricted maximum likelihood estimate (RMLE), a Bayes estimator, and a linear Bayes estimator. In our model, the conditional likelihood with RMLE of the nuisance parameters is equivalent to Bartlett's bias-corrected estimating function. In the simulation we show that Lindsay's conditional likelihood is in general preferred, irrespective of the estimator of the nuisance parameters. Although the integrated likelihood has smaller MSE when the precise nature of the prior distribution of the nuisance parameters is known, this approach may perform poorly in cases where the prior distribution of the nuisance parameters is not known, especially using a non-informative prior. In practice, Lindsay's method using the RMLE of the nuisance parameters is recommended.