Introduction to sample size determination and power analysis for clinical trials

Publication Description
The importance of sample size evaluation in clinical trials is reviewed and a general method is presented from which specific equations are derived for sample size determination or the analysis of power for a wide variety os statistical procedures. The method is discussed and illustrated in relation to the t test, tests for proportions, tests of survival time, and tests for correlations as they commonly occur in clinical trials. Most of the specific equations reduce to a simple general form for which tables are presented.

Primary Author
Lachin,John M.

Volume
2

Issue
2

Start Page
93

Other Pages
113

Publisher
Elsevier Inc

URL
https://www.sciencedirect.com/science/article/pii/0197245681900015

PMID
7273794



Reference Type
Journal Article

Periodical Full
Controlled Clinical Trials

Publication Year
1981

Place of Publication
United States

ISSN/ISBN
0197-2456

Document Object Index
10.1016/0197-2456(81)90001-5