Major issues in the organization and implementation of the national cooperative Gallstone Study (NCGS)

Publication Description
The National Cooperative Gallstone Study (NCGS) was a cooperative, randomized, controlled trial of a drug, chenodiol, for the medical dissolution of gallstones. The design and procedures of the NCGS were complex, having developed as a result of extensive involvement of many experts in the field of gallstone disease and biliary lipids. During the design and implementation of the protocol, many important issues required consideration and resolution. The aim of this article is to review these issues and the deliberations surrounding their resolution and provide personal conclusions and recommendations that may be helpful to other investigators involved in cooperative, controlled trials.

Primary Author
Marks,Jay W.
Croke,Gloria
Gochman,Nathan
Hofmann,Alan F.
Lachin,John M.
Schoenfield,Leslie J.
Tyor,Malcolm P.

Volume
5

Issue
1

Start Page
1

Other Pages
12

Publisher
Elsevier Inc

URL
https://www.sciencedirect.com/science/article/pii/0197245684901466

PMID
6713905



Reference Type
Journal Article

Periodical Full
Controlled Clinical Trials

Publication Year
1984

Place of Publication
United States

ISSN/ISBN
0197-2456

Document Object Index
10.1016/0197-2456(84)90146-6