Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control

Publication Description
To identify genetic variants associated with diabetic retinopathy (DR), we performed a large multiethnic genome-wide association study. Discovery included eight European cohorts ( = 3,246) and seven African American cohorts ( = 2,611). We meta-analyzed across cohorts using inverse-variance weighting, with and without liability threshold modeling of glycemic control and duration of diabetes. Variants with a value

Primary Author
Pollack,Samuela
Igo,Jr,Robert P.
Jensen,Richard A.
Christiansen,Mark
Li,Xiaohui
Cheng,Ching-Yu
Ng,Maggie C. Y.
Smith,Albert V.
Rossin,Elizabeth J.
Segrè,Ayellet V.
Davoudi,Samaneh
Tan,Gavin S.
Chen,Yii-Der Ida
Kuo,Jane Z.
Dimitrov,Latchezar M.
Stanwyck,Lynn K.
Meng,Weihua
Hosseini,S. M.
Imamura,Minako
Nousome,Darryl
Kim,Jihye
Hai,Yang
Jia,Yucheng
Ahn,Jeeyun
Leong,Aaron
Shah,Kaanan
Park,Kyu Hyung
Guo,Xiuqing
Ipp,Eli
Taylor,Kent D.
Adler,Sharon G.
Sedor,John R.
Freedman,Barry I.
Lee,I-T
Sheu,Wayne H. -H
Kubo,Michiaki
Takahashi,Atsushi
Hadjadj,Samy
Marre,Michel
Tregouet,David-Alexandre
Mckean-Cowdin,Roberta
Varma,Rohit
McCarthy,Mark I.
Groop,Leif
Ahlqvist,Emma
Lyssenko,Valeriya
Agardh,Elisabet
Morris,Andrew
Doney,Alex S. F.
Colhoun,Helen M.
Toppila,Iiro
Sandholm,Niina
Groop,Per-Henrik
Maeda,Shiro
Hanis,Craig L.
Penman,Alan
Chen,Ching J.
Hancock,Heather
Mitchell,Paul
Craig,Jamie E.
Chew,Emily Y.
Paterson,Andrew D.
Grassi,Michael A.
Palmer,Colin
Bowden,Donald W.
Yaspan,Brian L.
Siscovick,David
Cotch,Mary Frances
Wang,Jie Jin
Burdon,Kathryn P.
Wong,Tien Y.
Klein,Barbara E. K.
Klein,Ronald
Rotter,Jerome I.
Iyengar,Sudha K.
Price,Alkes L.
Sobrin,Lucia

Volume
68

Issue
2

Start Page
441

Other Pages
456

Publisher
American Diabetes Association

URL
https://www.ncbi.nlm.nih.gov/pubmed/30487263 https://www.ncbi.nlm.nih.gov/pubmed/30487263



Reference Type
Journal Article

Periodical Full
Diabetes (New York, N.Y.)

Publication Year
2019

Publication Date
Feb

Place of Publication
United States

ISSN/ISBN
0012-1797

Document Object Index
10.2337/db18-0567