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Predictors of response to insulin therapy in youth with poorly‐controlled type 2 diabetes in the TODAY trial

Objective To understand the factors associated with glycemic control after starting insulin in youth with type 2 diabetes following glycemic failure (persistent HbA1c ≥8%) with metformin alone, metformin + rosiglitazone or metformin + lifestyle in the TODAY study. Methods Change in HbA1c after add‐on insulin therapy and the factors predictive of glycemic response were evaluated. At 1‐year postinsulin initiation, 253 youth had a mean of 3.9 ± 1.0 visits since the time of insulin initiation. Participants were divided into three groups according to glycemic control: consistent decrease in HbA1c by ≥0.5%, change

Primary Author
El ghormli,Laure
Laffel,Lori M.
Macleish,Sarah A.
McKay,S.
Haymond,M.
Anderson,B.
Bush,C.
Holden,H.
Jeha,G.
McGirk,S.
Thamotharan,S.
Cuttler,L.
Abrams,E.
Ievers‐Landis,C.
Kaminski,B.
Koontz,M.
MacLeish,S.
Narasimhan,S.
Barraza,V.
Chang,N.
Dreimane,D.
Estrada,S.
Fisher,L.
Fleury‐Milfort,E.
Hernandez,S.
Kaufman,F.
Miller,D.
Muñoz,C.
Berkowitz,R.
Johnson,B.
Kaplan,J.
Keating,C.
McGinley,G.
McKnight,H.
Willi,S.
Bacha,F.
Libman,I.
Porter,K.
Venditti,E.
Gallagher,D.
Kringas,P.
Seidman,D.
Malloy,M.
Rasbach,L.
Angelescu,A.
Ciccarelli,C.
Delahanty,L.
Levitsky,L.
McEachern,R.
Norman,D.
Sherry,N.
Tollefsen,S.
Dempsher,D.
Flomo,D.
Whelan,T.
Wolff,B.
Weinstock,R.
Izquierdo,R.
Saletsky,R.
Zeitler,P.
Abramson,N.
Bradhurst,A.
Copeland,K.
Boss,E.
Brown,R.
Chalmers,L.
Chernausek,S.
Newgent,R.
Nordyke,A.
Poulsen,T.
Pratt,L.
Amodei,N.
Barajas,R.
Hernandez,J.
Wauters,A.
White,N.
Arbeláez,A.
Jones,J.
Tanner,M.
Timpson,A.
Welch,R.
Grey,M.
Guandalini,C.
Syme,A.
Long,C.
Marcovina,S. M.
Fan,B.
Marquez,L.
Mayer‐Davis,E.
Liu,Y.
Gidding,S.
Puccella,J.
Danis,R.
Domalpally,A.
Massmann,C.
Tibbs,T.
Van Buren,D.
Ratner,R.
Dremaine,D.
Silverstein,J.

Volume
20

Issue
7

Start Page
871

Other Pages
879

Publisher
John Wiley & Sons A/S

URL
https://onlinelibrary.wiley.com/doi/abs/10.1111/pedi.12906

PMID
31418516


Reference Type
Journal Article

Periodical Full
Pediatric diabetes

Publication Year
2019

Publication Date
Nov

Place of Publication
Former Munksgaard

ISSN/ISBN
1399-543X

Document Object Index
10.1111/pedi.12906