Utility of using electrocardiogram measures of heart rate variability as a measure of cardiovascular autonomic neuropathy in type 1 diabetes patients

Publication Description
Aims/Introduction Cardiovascular autonomic neuropathy (CAN) is a predictor of cardiovascular disease and mortality. Cardiovascular reflex tests (CARTs) are the gold standard for the diagnosis of CAN, but might not be feasible in large research cohorts or in clinical care. We investigated whether measures of heart rate variability obtained from standard electrocardiogram (ECG) recordings provide a reliable measure of CAN. Materials and Methods Standardized CARTs (R‐R response to paced breathing, Valsalva, postural changes) and digitized 12‐lead resting ECGs were obtained concomitantly in Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications participants (n = 311). Standard deviation of normally conducted R‐R intervals (SDNN) and the root mean square of successive differences between normal‐to‐normal R‐R intervals (rMSSD) were measured from ECG. Sensitivity, specificity, probability of correct classification and Kappa statistics evaluated the agreement between ECG‐derived CAN and CARTs‐defined CAN. Results Participants with CARTs‐defined CAN had significantly lower SDNN and rMSSD compared with those without CAN (P 

Primary Author
Pop‐Busui,Rodica
Backlund,Jye‐Yu C.
Bebu,Ionut
Braffett,Barbara H.
Lorenzi,Gayle
White,Neil H.
Lachin,John M.
Soliman,Elsayed Z.

Volume
13

Issue
1

Start Page
125

Other Pages
133

Publisher
John Wiley & Sons, Inc

URL
https://onlinelibrary.wiley.com/doi/abs/10.1111/jdi.13635

PMID
34309223



Reference Type
Journal Article

Periodical Full
Journal of diabetes investigation

Publication Year
2022

Publication Date
Jan

Place of Publication
Japan

ISSN/ISBN
2040-1116

Document Object Index
10.1111/jdi.13635