Maternal Morbidity and Mortality During the COVID-19 Pandemic (MFMU-COVID-19)

The two primary objectives are:

     1) to determine whether pregnant or immediately postpartum women experience higher maternal morbidity and mortality during the COVID-19 pandemic than before the pandemic and

     2) to determine whether women with COVID-19 infection have higher maternal morbidity and mortality than pregnant women without COVID-19 infection.

Secondary objectives include: 

     1) to determine which hospital, healthcare system, and community-level factors are associated with maternal morbidity and mortality in the current COVID-19 pandemic,

     2) to determine whether COVID-19 infection is associated with adverse maternal and neonatal outcomes,

     3) to evaluate whether vertical or postnatal transmission of COVID-19 occurs from mother to fetus/neonate, and

     4) to evaluate whether COVID-19 infection in pregnancy is associated with increased use of healthcare resources compared with pregnant women without infection.

The primary endpoint is a maternal composite defined as at least one of the following during pregnancy and through 6 weeks postpartum: morbidity from hypertensive disorders of pregnancy, morbidity from postpartum hemorrhage, morbidity from infection.



Rebecca Clifton




Project Overview:

This is a cohort study to compare maternal morbidity and mortality among pregnant and postpartum women with COVID-19 with those without the infection, and also to compare morbidity and mortality of this cohort to pre-pandemic deliveries.

Funding Agency or Sponsor: