Studies to Treat or Prevent Pediatric Type 2 Diabetes: TODAY2 Phase 2 Follow-up (T2P2)
In this follow-up study to the TODAY clinical trial, T2P2 will evaluate the rates of comorbidities and complications in the TODAY cohort and will compare with rates for children with type 1 diabetes with a similar age of onset and with adult-onset type 2 diabetes. Two hypotheses will be tested: (1) youth-onset T2D will progress rapidly and result in high rates of diabetes-related medical complications and comorbidities and (2) the rapid rate of progression is related to increased insulin resistance characteristic of puberty, worse β-cell function, degree of glycemic control, control of non-glycemic factors, and obesity itself.
- PRINCIPAL INVESTIGATORS
- ADDITIONAL INVESTIGATORS
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Barbara H. Braffett, PhD, Diane Uschner, PhD
- RESEARCH STAFF
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Brian Burke, Laure El ghormli, Mihili Gunaratne, Jason Stonewall, Bereket Tesfaldet, Melinda Tung, Meghan Turney, Jeff Weir, Shirley Zhou
- MAJOR PUBLICATIONS
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TODAY Study Group. Treatment options for type 2 diabetes in adolescents and youth: a study of the comparative efficacy of metformin alone or in combination with rosiglitazone or lifestyle intervention in adolescents with type 2 diabetes. Pediatric Diabetes 2007; 8:74-87. PMC2752327
TODAY Study Group. A clinical trial to maintain glycemic control in youth with type 2 diabetes. NEJM 2012; 366:2247-2256. PMC3478667
Gandica R and Zeitler P. Update on youth-onset type 2 diabetes: lessons learned from the Treatment Options for Type 2 Diabetes in Adolescents and Youth clinical trial. Advances in Pediatrics 2016; 63:195-209. PMC4955876
Zeitler P, Hirst K, Copeland KC, El ghormli L, Katz LL, Levitsky LL, Linder B, McGuigan P, White NH, Wilfley D for the TODAY Study Group. HbA1c after a short period of monotherapy with metformin identifies durable glycemic control among adolescents with type 2 diabetes. Diabetes Care 2015; 38:2285–2292. PMC4657618
Klingensmith GJ, Pyle L, Nadeau KJ, Barbour LA, Goland RS, Willi SM, Linder B, White NH for the TODAY Study Group. Pregnancy outcomes in youth with type 2 diabetes: the TODAY study experience. Diabetes Care 2016; 39:122-129. PMC4686849
Project Overview
TODAY2 is the long term follow-up of the youth from TODAY, to track the progression of type 2 diabetes (T2D) and related comorbidities and complications in the TODAY cohort as they transition to young adulthood.
Project Overview
TODAY2 is the long term follow-up of the youth from TODAY, to track the progression of type 2 diabetes (T2D) and related comorbidities and complications in the TODAY cohort as they transition to young adulthood.